Streptozotocin is similar enough to glucose to be transported into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. Fotemustine, lomustine, nimustine, and semustine block DNA replication. Gynura procumbens (Lour.) This study investigated the beneficial effects and mechanism of action of the juice of Momordica charantia in streptozotocin (STZ)-induced diabetes mellitus in rats. Some investigators have combined a partial pancreatectomy with a reduced STZ dose in pigs (Wise et al., 1985). Both compounds are taken up by GLUT2 transporters, act intracellularly, are selectively toxic … In a recent study, streptozotocin demonstrated activity against S. aureus by inhibiting the SaeRS two-component system (TCS) responsible for transcriptional regulation of different virulence factors of S. aureus, including adhesins, toxins, and enzymes [7]. The moderate-to-high dose model was designed to overcome the resistance of certain mouse strains to STZ-induced injury. 2-Deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-, CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O, InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1, "Studies of streptozotocin-induced insulitis and diabetes", "N-acetylcysteine protects memory decline induced by streptozotocin in mice", "An N-nitrosating metalloenzyme constructs the pharmacaphore of streptozotocin", "Drugs producing diabetes through damage of the insulin secreting cells", https://en.wikipedia.org/w/index.php?title=Streptozotocin&oldid=963446721, Chemical articles with unknown parameter in Infobox drug, Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields, Creative Commons Attribution-ShareAlike License, This page was last edited on 19 June 2020, at 21:09. Streptozocin is an N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. Res. [4] Streptozotocin is similar enough to glucose to be transported into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Thus streptozotocin has the potential to be developed as an anti-virulence agent against S. aureus infections. Alloxan: mechanism of action Alloxan has two distinct pathological effects: it selec-tively inhibits glucose-induced insulin secretion through specific inhibition of glucokinase, the glucose sensor of Fig. A typical dose is 500 mg/m 2 /day by intravenous injection, for 5 days, repeated every 4-6 weeks. Potentially fatal renal toxicity and hepatotoxicity have occurred. Streptozocin is a nitrosourea marketed for the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin acts as an alkylating agent which damages DNA by adding methyl and other alkyl groups which interfere with normal base pairing. Mechanism of action. It is used in medicine for treating certain cancers of the islets of Langerhans and used in medical research to produce an animal model for hyperglycemia and Alzheimer's in a large dose, as well as type 2 diabetes or type 1 diabetes with multiple low doses. Streptozotocin is an antimicrobial agent and has also been used as a chemotherapeutic alkylating agent . Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat Ijaz Ahmed 5266034.xml Molecular and Cellular Biochemistry 5266034 February 23, 2004 13:29 TECHBOOKS Molecular … Zahraa Mohammed-Ali, ... Jeffrey G. Dickhout, in Animal Models for the Study of Human Disease (Second Edition), 2017. Animal models of STZ-induced DN are usually performed in mice, Sprague–Dawley, WKY, and SHR rats. Due to its high toxicity to beta cells, in scientific research, streptozotocin has also been long used for inducing insulitis and diabetes on experimental animals. It is used as an antineoplastic agent and to induce diabetes in experimental animals. The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin. In summary, an induction of diabetes with streptozotocin resulted in significant increases in GLUT-4 phosphorylation. Streptozotocin is very soluble in water, lower alcohols and ketones. The two main type of STZ administration include multiple low-dose and moderate-to-high dose. It is stable for 3 years under refrigeration. Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line. Diabetologia. 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